how the body metabolizes or degrades the drug.how the body distributes the drug into different bodily compartments or tissues.how the drug is absorbed after administration.PK parameters are used to translate and understand how a drug interacts with the body. In drug development, PK and PD parameters are used to understand this complex interplay between drugs and the body to design, refine, and create safe and effective therapeutics. Pharmacodynamics (PD) describes how biological processes in the body respond to or are impacted by a drug. Pharmacokinetics (PK) describes the absorption, distribution, metabolism, and excretion (also known as ADME) of drugs in the body. These complicated interactions are measured and described using pharmacokinetic and pharmacodynamic parameters. ![]() DMPK and Translational Discovery and DevelopmentĪ complex biochemical “dance” occurs between the body’s natural processes and the chemical composition of pharmaceutical drugs when taken by humans.Pharmacometrics (PMx), Pharmacokinetics, Pharmacodynamics (PK/PD).Model Informed Dose & Drug Development (MIDD).Clinical Pharmacology Integrated Drug Development. ![]() Clinical Pharmacology Modeling Simulation.Biostatistics and Statistical Programming. ![]()
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